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Effects of growth hormone and insulin-like growth factor-1 on postoperative muscle and substrate metabolism. Folke hammarqvist,1,2 ingmar wennström,3 and jan. In this way, they have made bacteria that produce insulin and human growth hormone, and have bred goats that produce human antithrombin. Adult growth hormone deficiency (ghd) is characterized by metabolic abnormalities associated with visceral obesity, impaired quality of life, and increased. Insulin-like growth factor 1 (igf-1) is a hormone that functions as the major mediator of growth hormone (gh)-stimulated somatic growth,. Somatostatin, an inhibitor of pituitary growth hormone secretion, effectively reduced insulin release (supplementary fig. But somatostatin failed to. 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